Interference duration of 5 mg/d biotin for Roche cobas e602 and Beckman UniCel DxI 800 of thyroid function tests lasted for 8 hours, while 10 mg/d biotin interfered with Roche cobas e602 or Beckman UniCel DxI 800 for 1 day or 2 days. Ingesting 5 or 10 mg/d of biotin for 7 days could produce positive or negative interference among the thyroid function tests at Roche cobas e602 and Beckman UniCel DxI 800 systems, but no interference on Abbott Architect 2000. The outcomes were compared the baseline with the several points after taking biotin at Roche cobas e602, Beckman UniCel DxI 800, and Abbott Architect 2000 immunoassay platforms, respectively. Analyte concentrations of thyroid function tests were measured at baseline prior to starting biotin and from 2 hours to 2 days after withdrawal of 5 and 10 mg/d biotin. Ten healthy adults were recruited with administration of 5 and 10 mg/d biotin for 7 days. The aim of the study was to systematically characterize the interference of biotin on thyroid function tests and biotin washout periods. The work cannot be used commercially without permission from the journal. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website ( This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. Supplemental digital content is available for this article. Supplemental Digital Content is available for this article. The authors have no funding and conflicts of interest to disclose. YZ and RW contributed equally to the work and share the first authorship. Assessment of biotin interference in thyroid function tests. How to cite this article: Zhang Y, Wang R, Dong Y, Huang G, Ji B, Wang Q.
∗Correspondence: Qing Wang, Department of Endocrinology, China-Japan Union Hospital of Jilin University, Changchun, China (e-mail: ).Ībbreviations: Anti-Tg = antithyroglobulin antibodies, anti-TPO = antithyroid peroxidase antibodies, anti-TSHR = TSH receptor antibody, T3 = total triiodothyronine, T4 = total thyroxine, Tg = thyroglobulin, TSH = thyroid-stimulating hormone. BDepartment of Nuclear Medicine, China-Japan Union Hospital of Jilin UniversityĬDepartment of Radiotherapy, The Tumor Hospital of Jilin ProvinceĭDepartment of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun, China.
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